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• This technique has revolutionized treatment of male factor sterility. • A single sperm is injected in to the oocyte using a robotic micromanipulator to achieve fertilization. • Even in patients with nil sperms we can retrieve few sperms from the testis using methods such as PESA (Percutaneous epididymal sperm aspiration, MESA (Micro epididymal sperm aspiration) and TESE (Testicular sperm extraction) • Impossible cases have become pregnant using the above techniques.